Camptothecin and Minor-Groove Binder Hybrid Molecules: Synthesis, Inhibition of Topoisomerase I, and Anticancer Cytotoxicity in Vitro
Author:
Affiliation:
1. Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G2, and Glaxo-Wellcome (US), P.O. Box 13358, Research Triangle Park, North Carolina 27709
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm9605804
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1. Bifunctional Reagents. Cross-Linking of Pancreatic Ribonuclease with a Diimido Ester1
2. DNA Topoisomerase I—Targeted Chemotherapy of Human Colon Cancer in Xenografts
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