Design, Synthesis, and Evaluation of Carbamate-Substituted Analogues of (+)-Discodermolide-Reference-Cited by-同舟云学术

Design, Synthesis, and Evaluation of Carbamate-Substituted Analogues of (+)-Discodermolide

Published:2004-12-22 Issue:2 Volume:7 Page:311-314
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Smith Amos B.¹,Freeze B. Scott¹,LaMarche Matthew J.¹,Hirose Tomoyasu¹,Brouard Ignacio¹,Rucker Paul V.¹,Xian Ming¹,Sundermann Kurt F.¹,Shaw Simon J.¹,Burlingame Mark A.¹,Horwitz Susan Band¹,Myles David C.¹

Affiliation:

1. Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, Kosan Biosciences, Inc., 3832 Bay Center Place, Hayward, California 94545, Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, 10461

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ol047686a

Reference37 articles.

1. The Microtubule-Stabilizing Agent Discodermolide Competitively Inhibits the Binding of Paclitaxel (Taxol) to Tubulin Polymers, Enhances Tubulin Nucleation Reactions More Potently than Paclitaxel, and Inhibits the Growth of Paclitaxel-Resistant Cells

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