Optimization of (2,3-Dihydro-1-benzofuran-3-yl)acetic Acids: Discovery of a Non-Free Fatty Acid-Like, Highly Bioavailable G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonist as a Glucose-Dependent Insulinotropic Agent-Reference-Cited by-同舟云学术

Optimization of (2,3-Dihydro-1-benzofuran-3-yl)acetic Acids: Discovery of a Non-Free Fatty Acid-Like, Highly Bioavailable G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonist as a Glucose-Dependent Insulinotropic Agent

Published:2012-04-18 Issue:8 Volume:55 Page:3960-3974
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Negoro Nobuyuki¹,Sasaki Shinobu¹,Mikami Satoshi¹,Ito Masahiro¹,Tsujihata Yoshiyuki¹,Ito Ryo¹,Suzuki Masami¹,Takeuchi Koji¹,Suzuki Nobuhiro²,Miyazaki Junichi²,Santou Takashi¹,Odani Tomoyuki¹,Kanzaki Naoyuki¹,Funami Miyuki²,Morohashi Akio¹,Nonaka Masami¹,Matsunaga Shinichiro¹,Yasuma Tsuneo²,Momose Yu¹

Affiliation:

1. Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1 Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan

2. Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 17-85 Jusohonmachi 2-chome, Yodogawa-ku, Osaka 532-8686, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300170m

Reference26 articles.

1. Pharmacological Agents That Directly Modulate Insulin Secretion

2. Sulfonylurea Induced β-Cell Apoptosis in Cultured Human Islets