p38α Mitogen-Activated Protein Kinase Inhibitors: Optimization of a Series of Biphenylamides to Give a Molecule Suitable for Clinical Progression-Reference-Cited by-同舟云学术

p38α Mitogen-Activated Protein Kinase Inhibitors: Optimization of a Series of Biphenylamides to Give a Molecule Suitable for Clinical Progression

Published:2009-09-22 Issue:20 Volume:52 Page:6257-6269
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Aston Nicola M.¹,Bamborough Paul¹,Buckton Jacqueline B.¹,Edwards Christopher D.¹,Holmes Duncan S.¹,Jones Katherine L.¹,Patel Vipulkumar K.¹,Smee Penny A.¹,Somers Donald O.¹,Vitulli Giovanni¹,Walker Ann L.¹

Affiliation:

1. GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Rd, Stevenage, Hertfordshire SG1 2NY, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9004779

Reference25 articles.

1. Immunotherapy for rheumatoid arthritis

2. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

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4. New Approaches to the Treatment of Inflammatory Disorders Small Molecule inhibitors of p38 MAP Kinase

5. Pathway to the Clinic: Inhibition of P38 MAP Kinase. A Review of Ten Chemotypes Selected for Development

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