1. Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Chicago, Illinois 60611, Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637, Department of Molecular Biology and Biophysics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, Department of Medicinal Chemistry, Isis Pharmaceutical Inc., Carlsbad, California 92008, and Department of Drug...