Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes
Author:
Affiliation:
1. Philipps-Universität Marburg, Fachbereich Chemie, Hans-Meerwein Strasse, D-35043 Marburg, Germany, and University of Pennsylvania, Department of Chemistry and The Wistar Institute, Philadelphia, Pennsylvania 19104
Publisher
American Chemical Society (ACS)
Subject
Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis
Link
https://pubs.acs.org/doi/pdf/10.1021/ja805555a
Reference10 articles.
1. The Protein Kinase Complement of the Human Genome
2. Generation of Monospecific Nanomolar Tyrosine Kinase Inhibitors via a Chemical Genetic Approach
3. Structural Bioinformatics-Based Design of Selective, Irreversible Kinase Inhibitors
4. Exploring Chemical Space with Organometallics: Ruthenium Complexes as Protein Kinase Inhibitors
5. Structure of PAK1 in an Autoinhibited Conformation Reveals a Multistage Activation Switch
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