Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core
Author:
Affiliation:
1. Departments of Chemical Research
2. Department of Chemical Research
3. Oncology
4. Structural Chemistry
5. Pharmaceutical Sciences
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ml100063w
Reference18 articles.
1. Discovery and Development of Aurora Kinase Inhibitors as Anticancer Agents
2. Aurora kinase inhibitors in preclinical and clinical testing
3. Mitotic requirement for aurora A kinase is bypassed in the absence of aurora B kinase
4. A Class of 2,4-Bisanilinopyrimidine Aurora A Inhibitors with Unusually High Selectivity against Aurora B†
5. Discovery, Synthesis, and in Vivo Activity of a New Class of Pyrazoloquinazolines as Selective Inhibitors of Aurora B Kinase
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