New Nucleotide-Competitive Non-Nucleoside Inhibitors of Terminal Deoxynucleotidyl Transferase: Discovery, Characterization, and Crystal Structure in Complex with the Target-Reference-Cited by-同舟云学术

New Nucleotide-Competitive Non-Nucleoside Inhibitors of Terminal Deoxynucleotidyl Transferase: Discovery, Characterization, and Crystal Structure in Complex with the Target

Published:2013-09-12 Issue:18 Volume:56 Page:7431-7441
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Costi Roberta¹,Cuzzucoli Crucitti Giuliana¹,Pescatori Luca¹,Messore Antonella¹,Scipione Luigi¹,Tortorella Silvano¹,Amoroso Alessandra²,Crespan Emmanuele²,Campiglia Pietro³,Maresca Bruno³,Porta Amalia³,Granata Ilaria³,Novellino Ettore⁴,Gouge Jérôme⁵,Delarue Marc⁵,Maga Giovanni²,Di Santo Roberto¹

Affiliation:

1. Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur—Fondazione Cenci Bolognetti, “Sapienza” Università di Roma, P.le Aldo Moro 5, I-00185 Roma, Italy

2. Institute of Molecular Genetics IGM-CNR, Via Abbiategrasso 207, I-27100 Pavia, Italy

3. Department of Pharmaceutical and BioMedical Sciences, University of Salerno, I-84084 Fisciano, Salerno, Italy

4. Dipartimento di Farmacia, Università di Napoli “Federico II”, Via D. Montesano 49, I-80131 Napoli, Italy

5. Dynamique Structurale des Macromolecules, UMR 3528, CNRS, Institut Pasteur, 25 Rue du Dr Roux, 75015 Paris, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm4010187

Reference36 articles.

1. DNA replication and recombination

2. Thermal Conversion of Nonpriming Deoxyribonucleic Acid to Primer

3. Chemically Defined Templates and Initiators for Deoxypolynucleotide Synthesis

4. Calf Thymus Polymerase

5. Terminal deoxynucleotidyl transferasecatalysis of DNA (oligodeoxynucleotide) phosphorylation

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