A Diastereoselective Synthesis of 2,4-Disubstituted Piperidines:  Scaffolds for Drug Discovery

Author:

Watson Paul S.1,Jiang Bin1,Scott Brian1

Affiliation:

1. Dupont Pharmaceuticals Company, Route 141 and Henry Clay Road, Wilmington, Delaware 19880

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference10 articles.

1. A substructure search of the piperidine ring using the electronic version of the Drug Data Report (MDL Drug Data Report) which includes data from July 1988 through December 1998 revealed over 12 000 discrete piperidine entities that have been mentioned in clinical or preclinical studies.

2. Plasma concentrations of excitatory amino acids, serine, glycine, taurine and histidine in major depression

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