Discovery of Novel N-Phenylphenoxyacetamide Derivatives as EthR Inhibitors and Ethionamide Boosters by Combining High-Throughput Screening and Synthesis-Reference-Cited by-同舟云学术

Discovery of Novel N-Phenylphenoxyacetamide Derivatives as EthR Inhibitors and Ethionamide Boosters by Combining High-Throughput Screening and Synthesis

Published:2012-07-17 Issue:14 Volume:55 Page:6391-6402
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Flipo Marion¹²³⁴⁵,Willand Nicolas¹²³⁴⁵,Lecat-Guillet Nathalie¹⁴⁵⁶⁷,Hounsou Candide¹²³⁴⁵,Desroses Matthieu¹²³⁴⁵,Leroux Florence¹²³⁴⁵,Lens Zoé¹⁸⁹,Villeret Vincent¹⁸,Wohlkönig Alexandre¹⁰,Wintjens René¹¹,Christophe Thierry¹²,Kyoung Jeon Hee¹²,Locht Camille¹⁴⁶⁷¹³,Brodin Priscille¹⁴⁶⁷¹³,Baulard Alain R¹⁴⁵⁶⁷,Déprez Benoit¹²³⁴⁵

Affiliation:

1. Université Lille Nord de France, F-59000 Lille, France

2. Biostructures and Drug Discovery, Institut National de la Santé et de la Recherche Médicale (INSERM) U761, F-59000 Lille, France

3. Université Droit & Santé (UDSL), F-59000 Lille, France

4. Institut Pasteur de Lille, F-59019 Lille, France

5. Pôle de Recherche Interdisciplinaire sur le Médicament (PRIM), F-59000 Lille, France

6. INSERM U1019, F-59000 Lille, France

7. Centre National de Recherche Scientifique (CNRS) UMR8204, F-59021 Lille, France

8. Institut de Recherche Interdisciplinaire (IRI), CNRS USR3078, F-59658 Villeneuve d’Ascq, France

9. Laboratory of Molecular Virology, Institut de Biologie et de Médecine Moleculaires (IBMM), Université Libre de Bruxelles (ULB), 6041 Gosselies, Belgium

10. Structural Biology Brussels and Molecular and Cellular Interactions, Vlaams Instituut voor Biotechnologie (VIB), 1050 Brussels, Belgium

11. Laboratoire des Biopolymères et des Nanomatériaux Supramoléculaires, Institut de Pharmacie, ULB, 1050 Brussel, Belgium

12. Biology of Intracellular Pathogens INSERM-Avenir, Institut Pasteur Korea (IPK), 463-400 Gyeonggi-do, South Korea

13. Center for Infection and Immunity of Lille, F-59019 Lille, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300377g

Reference39 articles.

1. Are we really that good at treating tuberculosis?

2. Annulling a dangerous liaison: vaccination strategies against AIDS and tuberculosis

3. Scale up: meeting targets in global tuberculosis control

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