Molecular Tuning of a Vitamin E-Scaffold pH-Sensitive and Reductive Cleavable Lipid-like Material for Accelerated in Vivo Hepatic siRNA Delivery-Reference-Cited by-同舟云学术

Molecular Tuning of a Vitamin E-Scaffold pH-Sensitive and Reductive Cleavable Lipid-like Material for Accelerated in Vivo Hepatic siRNA Delivery

Published:2015-08-20 Issue:9 Volume:1 Page:834-844
ISSN:2373-9878
Container-title:ACS Biomaterials Science & Engineering
language:en
Short-container-title:ACS Biomater. Sci. Eng.

Author:

Akita Hidetaka¹,Noguchi Yuki¹,Hatakeyama Hiroto¹,Sato Yusuke¹,Tange Kota²,Nakai Yuta²,Harashima Hideyoshi¹

Affiliation:

1. Laboratory for Molecular Design of Pharmaceutics, Faculty of Pharmaceutical Science, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo, Japan

2. NOF Corporation, 3-3 Chidori-cho, Kawasaki-ku, Kawasaki, Kanagawa 210-0865, Japan

Funder

NOF CORPORATION

New Energy and Industrial Technology Development Organization

Japan Society for the Promotion of Science

Asahi Glass Foundation

Publisher

American Chemical Society (ACS)

Subject

Biomedical Engineering,Biomaterials

Link

https://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.5b00203

Reference40 articles.

1. RNAi targeting PCSK9 decreases lipid levels in a human trial

2. Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial

3. In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus.

4. Hepatocyte-targeted RNAi Therapeutics for the Treatment of Chronic Hepatitis B Virus Infection

5. Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis

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