Tumor-Targeting Polycaprolactone Nanoparticles with Codelivery of Paclitaxel and IR780 for Combinational Therapy of Drug-Resistant Ovarian Cancer

Author:

Pan Qianqian12,Tian Jingjun1,Zhu Huihui1,Hong Liangjie3,Mao Zhengwei3ORCID,Oliveira Joaquim Miguel456,Reis Rui L.456,Li Xiao1

Affiliation:

1. Women’s Reproductive Health Laboratory of Zhejiang Province, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, P. R. China

2. Zhejiang Financial College, No. 118 Xueyuan Street, Hangzhou, Zhejiang 310018, P. R. China

3. MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China

4. 3B’s Research Group, I3Bs—Research Institute on Biomaterials, Biodegradables, and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Zona Industrial da Gandra, 4805-017 Barco GMR, Portugal

5. ICVS/3B’s—PT Government Associate Laboratory, 4710-057 Braga/Guimarães, Portugal

6. The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark, 4805-017 Barco, Guimarães, Portugal

Funder

Ministry of Education of the People's Republic of China

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Key Laboratory of Reproductive Genetics, Zhejiang University

Center for Uterine Cancer Diagnosis and Therapy Research of Zhejiang Province

Zhejiang Provincial Key Laboratory of Women's Reproductive Health

Publisher

American Chemical Society (ACS)

Subject

Biomedical Engineering,Biomaterials

Reference59 articles.

1. Global, Regional, and National Life Expectancy, All-Cause Mortality, and Cause-Specific Mortality for 249 Causes of Death, 1980–2015: A Systematic Analysis for the Global Burden of Disease Study 2015. Lancet: London, England, 2016, 388 (10053), 1459–1544.

2. The Application and Outcome of Standard of Care Treatment in Elderly Women with Ovarian Cancer: A Literature Review over the Last 10 Years

3. Cancer nanomedicine: progress, challenges and opportunities

4. Clinical Translation of Nanomedicine

5. Simultaneous Delivery of siRNA and Paclitaxel via a “Two-in-One” Micelleplex Promotes Synergistic Tumor Suppression

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