Generation of Self-Induced Myocardial Ischemia in Large-Sized Cardiac Spheroids without Alteration of Environmental Conditions Recreates Fibrotic Remodeling and Tissue Stiffening Revealed by Constriction Assays-Reference-Cited by-同舟云学术

Generation of Self-Induced Myocardial Ischemia in Large-Sized Cardiac Spheroids without Alteration of Environmental Conditions Recreates Fibrotic Remodeling and Tissue Stiffening Revealed by Constriction Assays

Published:2024-01-18 Issue:2 Volume:10 Page:987-997
ISSN:2373-9878
Container-title:ACS Biomaterials Science & Engineering
language:en
Short-container-title:ACS Biomater. Sci. Eng.

Author:

Paz-Artigas Laura¹²,González-Lana Sandra¹³,Polo Nicolás¹,Vicente Pedro⁴⁵,Montero-Calle Pilar⁶,Martínez Miguel A.¹⁷,Rábago Gregorio⁶,Serra Margarida⁴⁵^ORCID,Prósper Felipe⁸⁹¹⁰,Mazo Manuel M.⁸⁹^ORCID,González Arantxa¹¹¹¹²,Ochoa Ignacio¹²⁷^ORCID,Ciriza Jesús¹²⁷^ORCID

Affiliation:

1. Tissue Microenvironment (TME) Lab, Aragón Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza 50018, Spain

2. Institute for Health Research Aragón (IIS Aragón), Zaragoza 50009, Spain

3. BEONCHIP S.L., CEMINEM, Campus Río Ebro, Zaragoza 50018, Spain

4. Instituto de Biologia Experimental e Tecnológica (iBET), Oeiras 2780-157, Portugal

5. Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras 2780-157, Portugal

6. Cardiology and Cardiac Surgery Department, Clínica Universidad de Navarra, Pamplona 31009, Spain

7. CIBER-BBN, ISCIII, Zaragoza 50018, Spain

8. Regenerative Medicine Program, Cima Universidad de Navarra, and Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona 31008, Spain

9. Hematology and Cell Therapy, Clínica Universidad de Navarra, and Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona 31008, Spain

10. CIBERONC, Instituto de Salud Carlos III, Madrid 28029, Spain

11. Program of Cardiovascular Diseases, CIMA Universidad de Navarra, and Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona 31008, Spain

12. CIBERCV, Instituto de Salud Carlos III, Madrid 28029, Spain

Funder

Gobierno de Arag?n

Ministerio de Ciencia e Innovaci?n

European Regional Development Fund

Gobierno de Navarra

Horizon 2020 Framework Programme

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.3c01302

Reference29 articles.

1. 3D Cardiac Cell Culture: A Critical Review of Current Technologies and Applications

2. Engineered Human Cardiac Microtissues: The State-of-the-(He)art

3. Current approaches for the recreation of cardiac ischaemic environment in vitro

4. Ischemic Heart Disease

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