Light-Sheet Microscopic Imaging of Whole-Mouse Vascular Network with Fluorescent Microsphere Perfusion
Author:
Affiliation:
1. School of Biomedical Engineering, School of Chemistry and Chemical Engineering, National Center for Translational Medicine, Shanghai Jiao Tong University, 200240 Shanghai, China
Funder
National Key Research and Development Program of China
Science and Technology Commission of Shanghai Municipality
National Natural Science Foundation of China
Publisher
American Chemical Society (ACS)
Link
https://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.4c00546
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1. Network-driven anomalous transport is a fundamental component of brain microvascular dysfunction
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4. Decreased blood vessel density and endothelial cell subset dynamics during ageing of the endocrine system
5. Brain microvasculature has a common topology with local differences in geometry that match metabolic load
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