1. Department of Chemistry, Materials, and Chemical Engineering “G. Natta”, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133Milan, Italy
2. Molecular Medicine Department (DMM), Center for Health Technologies (CHT), UdR INSTM, University of Pavia, 27100Pavia, Italy
3. Department of Public Health, Experimental and Forensic Medicine, Histology and Embryology Unit, University of Pavia, 27100Pavia, Italy
4. National Reference Center for Alternative Methods, Welfare and Care of Laboratory Animals, Istituto Zooprofilattico Sperimentale della Lomabardia ed Emilia Romagna, 25124Brescia, Italy
5. Medicina Clinica-Specialistica, UOR5 Laboratorio Di Nanotecnologie, ICS Maugeri, IRCCS, Pavia, Via Boezio, 28-27100Pavia, Italy
6. Interuniversity Center for the Promotion of the 3Rs Principles in Teaching and Research (Centro 3R), Università di Pavia Unit, 27100Pavia, Italy
7. Interuniversity Center for the Promotion of the 3Rs Principles in Teaching and Research (Centro 3R), Politecnico di Milano Unit, 20133Milan, Italy