An Ultrahigh Resolution Structure of TEM-1 β-Lactamase Suggests a Role for Glu166 as the General Base in Acylation-Reference-Cited by-同舟云学术

An Ultrahigh Resolution Structure of TEM-1 β-Lactamase Suggests a Role for Glu166 as the General Base in Acylation

Published:2002-04-20 Issue:19 Volume:124 Page:5333-5340
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Minasov George¹,Wang Xiaojun¹,Shoichet Brian K.¹

Affiliation:

1. Contribution from the Department of Molecular Pharmacology & Biological Chemistry, Northwestern University, 303 East Chicago Avenue, Chicago, Illinois 60611-3008

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja0259640

Reference57 articles.

1. Beta-lactamases and bacterial resistance to antibiotics

2. Structural transitions during activation and ligand binding in hexadecameric Rubisco inferred from the crystal structure of the activated unliganded spinach enzyme

3. Structure-Based Design Guides the Improved Efficacy of Deacylation Transition State Analogue Inhibitors of TEM-1 β-Lactamase,

4. Penicillin resistance: the chemistry of .beta.-lactamase inhibition

5. Site-directed mutagenesis on TEM-1 ß-lactamase: role of Glul66 in catalysis and substrate binding

Cited by 195 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The Evolution of the Acylation Mechanism in β-Lactamase and Rapid Protein Dynamics;ACS Catalysis;2024-08-28

2. Saturation Mutagenesis and Molecular Modeling: The Impact of Methionine 182 Substitutions on the Stability of β-Lactamase TEM-1;International Journal of Molecular Sciences;2024-07-13

3. Unsupervised evolution of protein and antibody complexes with a structure-informed language model;Science;2024-07-05

4. Electric Fields Are a Key Determinant of Carbapenemase Activity in Class A β-Lactamases;ACS Catalysis;2024-04-23

5. NeuroFold: A Multimodal Approach to Generating Novel Protein Variantsin silico;2024-03-14