Enantioselective Total Synthesis of (−)-Himalensine A via a Palladium and 4-Hydroxyproline Co-catalyzed Desymmetrization of Vinyl-bromide-tethered Cyclohexanones-Reference-Cited by-同舟云学术

Enantioselective Total Synthesis of (−)-Himalensine A via a Palladium and 4-Hydroxyproline Co-catalyzed Desymmetrization of Vinyl-bromide-tethered Cyclohexanones

Published:2023-02-23 Issue:9 Volume:145 Page:5422-5430
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Kučera Roman¹^ORCID,Ellis Sam R.¹,Yamazaki Ken¹²^ORCID,Hayward Cooke Jack¹^ORCID,Chekshin Nikita¹^ORCID,Christensen Kirsten E.¹,Hamlin Trevor A.²^ORCID,Dixon Darren J.¹^ORCID

Affiliation:

1. Department of Chemistry, Chemical Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, U.K.

2. Department of Theoretical Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS), and Amsterdam Center for Multiscale Modeling (ACMM), Vrije Universiteit Amsterdam, De Boelelaan 1083, Amsterdam 1081 HV, The Netherlands

Funder

AstraZeneca

Novartis

Defence Science and Technology Laboratory

Diamond Light Source

Pfizer

GlaxoSmithKline

Janssen Pharmaceuticals

Syngenta International

Engineering and Physical Sciences Research Council

Vertex Pharmaceuticals

Takeda Pharmaceutical Company