Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6-Reference-Cited by-同舟云学术

Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6

Published:2023-04-27 Issue:18 Volume:145 Page:10015-10021
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Van Horn Kurt S.¹,Wang Dongju¹²,Medina-Cleghorn Daniel¹,Lee Peter S.¹^ORCID,Bryant Clifford¹,Altobelli Chad¹,Jaishankar Priyadarshini¹,Leung Kevin K.¹^ORCID,Ng Raymond A.³,Ambrose Andrew J.¹^ORCID,Tang Yinyan¹,Arkin Michelle R.¹^ORCID,Renslo Adam R.¹^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th Street, San Francisco, California 94143, United States

2. School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China

3. Chempartner Corporation, 280 Utah Avenue, South San Francisco, California 94080, United States

Funder

Alzheimer's Association

National Institute on Aging

Cure Huntington's Disease Initiative

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.2c12240

Reference33 articles.

1. Caspases: Enemies Within

2. Apoptotic Pathways

3. Caspases in metabolic disease and their therapeutic potential

4. Caspase Functions in Cell Death and Disease

5. Caspase-6 and neurodegeneration

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