Systemic Concentrations Can Limit the Oral Absorption of Poorly Soluble Drugs: An Investigation of Non-Sink Permeation Using Physiologically Based Pharmacokinetic Modeling-Reference-Cited by-同舟云学术

Systemic Concentrations Can Limit the Oral Absorption of Poorly Soluble Drugs: An Investigation of Non-Sink Permeation Using Physiologically Based Pharmacokinetic Modeling

Published:2013-05-06 Issue:11 Volume:10 Page:3980-3988
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Chiang Po-Chang¹,La Hank¹,Zhang Haiming¹,Wong Harvey¹

Affiliation:

1. Department of Pharmaceutics, ‡Process Chemistry, and §Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/mp400088q

Reference25 articles.

1. Drug-like properties and the causes of poor solubility and poor permeability

2. Solubility and Dissolution Profile Assessment in Drug Discovery

3. Theoretical and Experimental Studies of Transport of Micelle-Solubilized Solutes

4. Predicting the impact of physiological and biochemical processes on oral drug bioavailability

5. Rate-Limiting Steps of Oral Absorption for Poorly Water-Soluble Drugs in Dogs; Prediction from a Miniscale Dissolution Test and a Physiologically-Based Computer Simulation

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