1. Faculty of Pharmaceutical Sciences, Kinki University, 3-4-1 Kowakae, Higashi-osaka 577-8502, Japan, Hokkaido University Hospital, Kita-14 Nishi-5, Kitaku, Sapporo 060-8648, Japan, Faculty of Health Sciences, Hokkaido University, Kita-12 Nishi-5, Kitaku, Sapporo 060-0812, Japan, and Department of Chemistry, College of Humanities and Sciences, Nihon University, 3-25-40 Sakurajousui, Setagaya, Tokyo 156-8550, Japan