Synthesis of a 5-((Aryloxy)methyl)-3-(4-(trifluoromethyl)phenyl)[1,2,4]thiadiazole Derivative: A Promising PPARα,δ Agonist
Author:
Affiliation:
1. Johnson and Johnson Pharmaceutical Research & Development, LLC, 1000 Route 202, Raritan, New Jersey 08869, U.S.A.
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/op700141u
Reference15 articles.
1. Synthesis and Identification of [1,2,4]Thiadiazole Derivatives as a New Series of Potent and Orally Active Dual Agonists of Peroxisome Proliferator-Activated Receptors α and δ
2. Activation of PPARδ alters lipid metabolism in db/db mice
3. The peroxisome proliferator-activated receptor , an integrator of transcriptional repression and nuclear receptor signaling
4. A selective peroxisome proliferator-activated receptor agonist promotes reverse cholesterol transport
5. Synthesis of 3,4-difluorobenzonitrile and monofluorobenzonitriles by means of halogen-exchange fluorination
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