Elucidation of Gephyronic Acid Biosynthetic Pathway Revealed Unexpected SAM-Dependent Methylations-Reference-Cited by-同舟云学术

Elucidation of Gephyronic Acid Biosynthetic Pathway Revealed Unexpected SAM-Dependent Methylations

Published:2013-12-03 Issue:12 Volume:76 Page:2269-2276
ISSN:0163-3864
Container-title:Journal of Natural Products
language:en
Short-container-title:J. Nat. Prod.

Author:

Young Jeanette¹,Stevens D. Cole¹,Carmichael Rory²,Tan John²,Rachid Shwan³,Boddy Christopher N.⁴,Müller Rolf³,Taylor Richard E.¹

Affiliation:

1. Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, United States

2. Genomics and Bioinformatics Core Facility, University of Notre Dame, Notre Dame, Indiana, United States

3. Helmholtz-Institut für Pharmazeutische Forschung Infektionsforschung and Pharmazeutische Biotechnologie, Universität des Saarlandes, Saarbrücken, Germany

4. Departments of Chemistry and Biology, University of Ottawa, Ottawa, Ontario, Canada

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/np400629v

Reference43 articles.

1. Antibiotics from gliding bacteria. No.61. Gephyronic Acid, a Novel Inhibitor of Eukaryotic Protein Synthesis from Archangium gephyra (Myxobacteria). Production, Isolation, Physico-chemical and Biological Properties, and Mechanism of Action.

2. Gephyronic Acid, a Missing Link between Polyketide Inhibitors of Eukaryotic Protein Synthesis (Part I): Structural Revision and Stereochemical Assignment of Gephyronic Acid

3. Gephyronic Acid, a Missing Link between Polyketide Inhibitors of Eukaryotic Protein Synthesis (Part II): Total Synthesis of Gephyronic Acid

4. Synthesis and Biological Evaluation of Gephyronic Acid Derivatives: Initial Steps towards the Identification of the Biological Target of Polyketide Inhibitors of Eukaryotic Protein Synthesis

5. Myxobacteria—‘microbial factories’ for the production of bioactive secondary metabolites

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