Semisynthesis of Antitumoral Acetogenins: SAR of Functionalized Alkyl-Chain Bis-Tetrahydrofuranic Acetogenins, Specific Inhibitors of Mitochondrial Complex I-Reference-Cited by-同舟云学术

Semisynthesis of Antitumoral Acetogenins: SAR of Functionalized Alkyl-Chain Bis-Tetrahydrofuranic Acetogenins, Specific Inhibitors of Mitochondrial Complex I

Published:2000-11-16 Issue:25 Volume:43 Page:4793-4800
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gallardo Teresa¹,Zafra-Polo M. Carmen¹,Tormo José R.¹,González M. Carmen¹,Franck Xavier¹,Estornell Ernesto¹,Cortes Diego¹

Affiliation:

1. Departamento de Farmacología, Laboratorio de Farmacognosia, and Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Valencia, 46100 Burjassot, Valencia, Spain, and Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université Paris-Sud, 92296 Châtenay-Malabry, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm000911j

Reference32 articles.

1. Molecular mode of action of annonins

2. Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase (Complex I)

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