Proton Transfer from C-6 of Uridine 5′-Monophosphate Catalyzed by Orotidine 5′-Monophosphate Decarboxylase: Formation and Stability of a Vinyl Carbanion Intermediate and the Effect of a 5-Fluoro Substituent-Reference-Cited by-同舟云学术

Proton Transfer from C-6 of Uridine 5′-Monophosphate Catalyzed by Orotidine 5′-Monophosphate Decarboxylase: Formation and Stability of a Vinyl Carbanion Intermediate and the Effect of a 5-Fluoro Substituent

Published:2012-08-21 Issue:35 Volume:134 Page:14580-14594
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Tsang Wing-Yin¹,Wood B. McKay²,Wong Freeman M.³,Wu Weiming³,Gerlt John A.²,Amyes Tina L.¹,Richard John P.¹

Affiliation:

1. Department of Chemistry, University at Buffalo, Buffalo, New York 14260, United States

2. Departments of Biochemistry and Chemistry, University of Illinois, Urbana, Illinois 61801, United States

3. Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, California 94132, United States

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja3058474

Reference70 articles.

1. Intrinsic Activity and Stability of Bifunctional Human UMP Synthase and Its Two Separate Catalytic Domains, Orotate Phosphoribosyltransferase and Orotidine-5′-phosphate Decarboxylase

2. Yeast Orotidine-5‘-Phosphate Decarboxylase: Steady-State and Pre-Steady-State Analysis of the Kinetic Mechanism of Substrate Decarboxylation

3. Catalytic Proficiency: The Unusual Case of OMP Decarboxylase

4. A Proficient Enzyme

5. Activation of Orotidine 5‘-Monophosphate Decarboxylase by Phosphite Dianion: The Whole Substrate is the Sum of Two Parts

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