1. Medicinal Chemistry Research Laboratories II, Pharmacology Research Laboratories II, and Strategic Research Planning, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd., 17-85, Jusohonmachi 2-Chome, Yodogawaku, Osaka 532-8686, Japan, and Product Planning, Strategic Product Planning Department, Takeda Chemical Industries, Ltd., 4-1-1 Doshomachi, Chuo-ku, Osaka 540-8645, Japan