Size and Molecular Flexibility of Sugars Determine the Storage Stability of Freeze-Dried Proteins
Author:
Affiliation:
1. Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
Funder
European Commission
Carbohydrate Competence Center
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/mp500423z
Reference36 articles.
1. Lyophilization and development of solid protein pharmaceuticals
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4. Unraveling protein stabilization mechanisms: Vitrification and water replacement in a glass transition temperature controlled system
5. Maintenance of Quaternary Structure in the Frozen State Stabilizes Lactate Dehydrogenase during Freeze–Drying
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