Structure-Based Design of Orally Bioavailable 1H-Pyrrolo[3,2-c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)-Reference-Cited by-同舟云学术

Structure-Based Design of Orally Bioavailable 1H-Pyrrolo[3,2-c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)

Published:2013-12-02 Issue:24 Volume:56 Page:10045-10065
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Naud Sébastien¹,Westwood Isaac M.¹²,Faisal Amir¹,Sheldrake Peter¹,Bavetsias Vassilios¹,Atrash Butrus¹,Cheung Kwai-Ming J.¹,Liu Manjuan¹,Hayes Angela¹,Schmitt Jessica¹,Wood Amy¹,Choi Vanessa¹,Boxall Kathy¹,Mak Grace¹,Gurden Mark³,Valenti Melanie¹,de Haven Brandon Alexis¹,Henley Alan¹,Baker Ross¹,McAndrew Craig¹,Matijssen Berry¹,Burke Rosemary¹,Hoelder Swen¹,Eccles Suzanne A.¹,Raynaud Florence I.¹,Linardopoulos Spiros¹³,van Montfort Rob L. M.¹²,Blagg Julian¹

Affiliation:

1. Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London SM2 5NG, United Kingdom

2. Division of Structural Biology, The Institute of Cancer Research, London SW3 6JB, United Kingdom

3. The Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London SW3 6JB, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm401395s

Reference49 articles.

1. The spindle checkpoint

2. The spindle-assembly checkpoint in space and time

3. The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint.

4. Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase.

5. Expression of TTK, a novel human protein kinase, is associated with cell proliferation.

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