Oxidative Metabolites of 5-S-Cysteinylnorepinephrine Are Irreversible Inhibitors of Mitochondrial Complex I and the α-Ketoglutarate Dehydrogenase and Pyruvate Dehydrogenase Complexes: Possible Implications for Neurodegenerative Brain Disorders
Author:
Affiliation:
1. Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019
Publisher
American Chemical Society (ACS)
Subject
Toxicology,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/tx990170t
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1. Astrocytes convert the parkinsonism inducing neurotoxin, MPTP, to its active metabolite, MPP+
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