Design of Small-Sized Libraries by Combinatorial Assembly of Linkers and Functional Groups to a Given Scaffold: Application to the Structure-Based Optimization of a Phosphodiesterase 4 Inhibitor-Reference-Cited by-同舟云学术

Design of Small-Sized Libraries by Combinatorial Assembly of Linkers and Functional Groups to a Given Scaffold: Application to the Structure-Based Optimization of a Phosphodiesterase 4 Inhibitor

Published:2005-05-07 Issue:11 Volume:48 Page:3816-3822
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Krier Mireille¹,de Araújo-Júnior João X.¹,Schmitt Martine¹,Duranton Jérôme¹,Justiano-Basaran Hélène¹,Lugnier Claire¹,Bourguignon Jean-Jacques¹,Rognan Didier¹

Affiliation:

1. Laboratoire de Pharmacochimie de la Communication Cellulaire, UMR CNRS 7081, F-67401 Illkirch, France, IDEALP Pharma, BP 2132, F-69603 Villeurbanne, France, Curso de Farmácia, Departamento de Medicina Social, Departamento de Química, Universidade Federal de Alagoas, MACEIO-AL, 57072-970, Brasil, and Laboratoire de Pharmacologie et Physico-Chimie des Interactions Cellulaires et Moléculaires, UMR CNRS 7034, F-67401 Illkirch, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050063y

Reference40 articles.

1. A High-Flying Fix for Ozone Loss

2. Structure-based combinatorial library design: methodologies and applications

3. A fresh look at pharmaceutical screening library design

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