Rational Design of New Antituberculosis Agents:  Receptor-Independent Four-Dimensional Quantitative Structure−Activity Relationship Analysis of a Set of Isoniazid Derivatives

Author:

Pasqualoto Kerly F. M.1,Ferreira Elizabeth I.1,Santos-Filho Osvaldo A.1,Hopfinger Anton J.1

Affiliation:

1. LAPEN, Departamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Av. Prof. Lineu Prestes 580, Bloco 13 sup., São Paulo, SP, 05508-900, Brasil, and Laboratory of Molecular Modeling and Design (M/C-781), College of Pharmacy, The University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612-7231

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference40 articles.

1. Wolinsky, E. Tuberculosis. InCecil Textbook of Medicine, 19th ed.; Wyngaarden, J. B., Smith, L. H., Jr., Bennett, J. C., Eds.; W. B. Saunders Company:  Philadelphia, PA, 1992; Vol. 2, pp 1733−1742.

2. Country Profiles:  Brazil; Annual Report; World Health Organization, 1997 [www.who.int/gtb/publications/tbrep_97/countries/brazil.htm].

3. Tuberculosis; Fact Sheet No. 104 (revised in August 2002); World Health Organization, 2002 [www.who.int/mediacentre/factsheets/who104/en/index.htm].

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