Synthesis of trans-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine Opioid Antagonists: Application of the Cis-Thermal Elimination of Carbonates to Alkaloid Synthesis-Reference-Cited by-同舟云学术

Synthesis of trans-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine Opioid Antagonists: Application of the Cis-Thermal Elimination of Carbonates to Alkaloid Synthesis

Published:1996-01-01 Issue:2 Volume:61 Page:587-597
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Werner John A.¹,Cerbone Louis R.¹,Frank Scott A.¹,Ward Jeffrey A.¹,Labib Parviz¹,Tharp-Taylor Roger W.¹,Ryan C. W.¹

Affiliation:

1. Chemical Process Research and Development, Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, Indiana 46285-4813

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo951403y

Reference31 articles.

1. New structural concepts for narcotic antagonists defined in a 4-phenylpiperidine series

2. Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for .mu.- and .kappa.-opioid receptors

3. 3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity

4. Selective opioid receptor agonists and antagonists: research tools and potential therapeutic agents

5. (b) Jaffe, J. H.; Martin, W. R. InGoodman and Gilman's the Pharmacological Basis of Therapeutics, 7th ed.; Gilman, A. G., Goodman, L. S., Rall, T. W., Murad, F., Eds.; Macmillan: New York, 1985; p 491.

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