1. Molecular Design and Information Technology Center, Leslie Dan Faculty of Pharmacy, 19 Russell Street, Toronto, ON M5S 2S2 Canada, Department of Chemistry, University of Toronto, Departments of Medical Biophysics, Biochemistry, and Molecular and Medical Genetics, 1 King's College Circle, Toronto, ON M5S 1A8, Canada, and Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, Princess Margaret Hospital, 610 University Avenue, Toronto, ON M5G 2M9, Canada