1. Applied Bioresearch Center, Research and Development Department, Kirin Brewery Company, Ltd., 3 Miyaharacho, Takasaki-shi, Gunma 370-1295, Japan and Pharmaceutical Development Laboratories, Pharmaceutical Division, Kirin Brewery Company, Ltd., 2-2 Souja-machi 1 chome, Maebashi-shi, Gunma 371-0853, Japan