Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), A Potent and Selective Cyclin-Dependent Kinase Inhibitor with Significant in Vivo Antitumor Activity-Reference-Cited by-同舟云学术

Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), A Potent and Selective Cyclin-Dependent Kinase Inhibitor with Significant in Vivo Antitumor Activity

Published:2006-09-30 Issue:22 Volume:49 Page:6549-6560
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chu Xin-Jie¹,DePinto Wanda¹,Bartkovitz David¹,So Sung-Sau¹,Vu Binh T.¹,Packman Kathryn¹,Lukacs Christine¹,Ding Qingjie¹,Jiang Nan¹,Wang Ka¹,Goelzer Petra¹,Yin Xuefeng¹,Smith Melissa A.¹,Higgins Brian X.¹,Chen Yingsi¹,Xiang Qing¹,Moliterni John¹,Kaplan Gerald¹,Graves Bradford¹,Lovey Allen¹,Fotouhi Nader¹

Affiliation:

1. Departments of Discovery Chemistry, Discovery Oncology, Non-Clinical Drug Safety and Discovery Technologies, Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, New Jersey 07110

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0606138

Reference38 articles.

1. CYCLIN-DEPENDENT KINASES: Engines, Clocks, and Microprocessors

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4. To cycle or not to cycle: a critical decision in cancer

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