Design, Synthesis, and X-ray Structure of Potent Memapsin 2 (β-Secretase) Inhibitors with Isophthalamide Derivatives as the P2-P3-Ligands-Reference-Cited by-同舟云学术

Design, Synthesis, and X-ray Structure of Potent Memapsin 2 (β-Secretase) Inhibitors with Isophthalamide Derivatives as the P2-P3-Ligands

Published:2007-04-14 Issue:10 Volume:50 Page:2399-2407
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ghosh Arun K.¹,Kumaragurubaran Nagaswamy¹,Hong Lin¹,Kulkarni Sarang S.¹,Xu Xiaoming¹,Chang Wanpin¹,Weerasena Vajira¹,Turner Robert¹,Koelsch Gerald¹,Bilcer Geoffrey¹,Tang Jordan¹

Affiliation:

1. Departments of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907, Athenagen Inc, Oklahoma City, Oklahoma 73104, Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, and Department of Biochemistry and Molecular Biology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm061338s

Reference27 articles.

1. Treatment of Alzheimer's disease; current status and new perspectives

2. Aβ-Generating Enzymes

3. Translating cell biology into therapeutic advances in Alzheimer's disease

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