Synthesis and Biological Activity of Conformationally Restricted Analogues of Milnacipran: (1S,2R)-1-Phenyl-2-[(R)-1-amino-2-propynyl]-N,N- diethylcyclopropanecarboxamide Is a Novel Class of NMDA Receptor Channel Blocker-Reference-Cited by-同舟云学术

Synthesis and Biological Activity of Conformationally Restricted Analogues of Milnacipran: (1S,2R)-1-Phenyl-2-[(R)-1-amino-2-propynyl]-N,N- diethylcyclopropanecarboxamide Is a Novel Class of NMDA Receptor Channel Blocker

Published:1998-08-01 Issue:18 Volume:41 Page:3507-3514
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Shuto Satoshi¹,Ono Shizuka¹,Imoto Hiroaki¹,Yoshii Kiyonori¹,Matsuda Akira¹

Affiliation:

1. Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan, Department of Biochemical Engineering and Science, Kyushu Institute of Technology, Iizuka 820-8502, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm980238m

Reference36 articles.

1. Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil

2. Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.

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