Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design-Reference-Cited by-同舟云学术

Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design

Published:2010-07-28 Issue:16 Volume:53 Page:5956-5969
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Woodhead Andrew J.¹,Angove Hayley²,Carr Maria G.¹,Chessari Gianni³,Congreve Miles¹,Coyle Joseph E.²,Cosme Jose⁴,Graham Brent⁵,Day Philip J.⁶,Downham Robert¹,Fazal Lynsey⁴,Feltell Ruth⁵,Figueroa Eva¹,Frederickson Martyn¹,Lewis Jonathan⁴,McMenamin Rachel⁵,Murray Christopher W.³,O’Brien M. Alistair¹,Parra Lina⁴,Patel Sahil⁶,Phillips Theresa¹,Rees David C.¹,Rich Sharna⁵,Smith Donna-Michelle⁴,Trewartha Gary¹,Vinkovic Mladen⁶,Williams Brian¹,Woolford Alison J.-A.¹

Affiliation:

1. Medicinal Chemistry

2. Biophysics

3. Computational Chemistry and Informatics

4. DMPK

5. Biology

6. Structural Biology

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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