A Catalytic Enantioselective Synthesis of the Endothelin Receptor Antagonists SB-209670 and SB-217242. A Base-Catalyzed Stereospecific Formal 1,3-Hydrogen Transfer of a Chiral 3-Arylindenol-Reference-Cited by-同舟云学术

A Catalytic Enantioselective Synthesis of the Endothelin Receptor Antagonists SB-209670 and SB-217242. A Base-Catalyzed Stereospecific Formal 1,3-Hydrogen Transfer of a Chiral 3-Arylindenol

Published:1998-04-23 Issue:18 Volume:120 Page:4550-4551
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Clark William M.¹,Tickner-Eldridge Ann M.¹,Huang G. Kris¹,Pridgen Lendon N.¹,Olsen Mark A.¹,Mills Robert J.¹,Lantos Ivan¹,Baine Neil H.¹

Affiliation:

1. Synthetic Chemistry Department SmithKline Beecham Pharmaceuticals 709 Swedeland Road, P.O. Box 1539 King of Prussia, Pennsylvania 19406

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja973882j

Reference14 articles.

1. A novel potent vasoconstrictor peptide produced by vascular endothelial cells

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3. Endothelin Receptors: From the Gene to the Human; Ruffolo, R. R., Jr., Ed.; CRC: Boca Raton, 1995.

4. 1,3-Diarylindan-2-carboxylic Acids, Potent and Selective Non-Peptide Endothelin Receptor Antagonists

5. Catalytic Behavior of Optically Active Amino Alcohol–Borane Complex in the Enantioselective Reduction of Acetophenone OximeO-Alkyl Ethers

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