A New Route to 7-Substituted Derivatives of N-{4-[2-(2-Amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)- ethyl]benzoyl}-l-glutamic Acid [ALIMTA (LY231514, MTA)]1-Reference-Cited by-同舟云学术

A New Route to 7-Substituted Derivatives of N-{4-[2-(2-Amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)- ethyl]benzoyl}-l-glutamic Acid [ALIMTA (LY231514, MTA)]1

Published:2001-05-09 Issue:11 Volume:66 Page:3726-3738
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Taylor Edward C.¹,Liu Bin¹

Affiliation:

1. Department of Chemistry, Princeton University, Princeton, New Jersey 08655

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo001580l

Reference43 articles.

1. A dideazatetrahydrofolate analog lacking a chiral center at C-6: N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5yl)ethyl[benzoyl]-L-glutamic acid is an inhibitor of thymidylate synthase

2. Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin

3. The 6S- and 6R-Diastereomers of 5, 10-Dideaza-5, 6, 7, 8-tetrahydrofolate Are Equiactive Inhibitors of de Novo Purine Synthesis

4. (a) Taylor, E. C.; Kuhnt, D.; Shih, C. InChemistry and Biology ofPteridines and Folates; Pfleiderer, W., Rokos, H. Eds.; Blackwell Science: Cambridge, MA, 1997; p 81.

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