An Imidazopiperidine Series of CCR5 Antagonists for the Treatment of HIV: The Discovery of N-{(1S)-1-(3-Fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798)-Reference-Cited by-同舟云学术

An Imidazopiperidine Series of CCR5 Antagonists for the Treatment of HIV: The Discovery of N-{(1S)-1-(3-Fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798)

Published:2010-12-03 Issue:1 Volume:54 Page:67-77
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Stupple Paul A.¹,Batchelor David V.¹,Corless Martin¹,Dorr Patrick K.¹,Ellis David¹,Fenwick David R.¹,Galan Sébastien R. G.¹,Jones Rhys M.¹,Mason Helen J.¹,Middleton Donald S.¹,Perros Manos¹,Perruccio Francesca¹,Platts Michelle Y.¹,Pryde David C.¹,Rodrigues Deborah¹,Smith Nicholas N.¹,Stephenson Peter T.¹,Webster Robert¹,Westby Mike¹,Wood Anthony¹

Affiliation:

1. Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent CT13 9NJ, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm100978n

Reference35 articles.

1. Current status of antiretroviral therapy

2. CCR5 inhibitors in HIV-1 therapy

3. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

4. The Discovery of the CCR5 Receptor Antagonist, UK-427,857, A New Agent for the Treatment of HIV Infection and AIDS

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