1. Department of Chemistry, The University of Michigan, Ann Arbor, Michigan 48109-1055, Department of Surgery and Molecular Integrative Physiology, The University of Michigan Medical Center, Ann Arbor, Michigan 48109-0656, Comprehensive Cancer Center, University of Michigan Medical Center, Ann Arbor, Michigan, and Department of Surgery, The University of Michigan Medical Center, Ann Arbor, Michigan 48109-0656