Complexes of HIV-1 Reverse Transcriptase with Inhibitors of the HEPT Series Reveal Conformational Changes Relevant to the Design of Potent Non-Nucleoside Inhibitors-Reference-Cited by-同舟云学术

Complexes of HIV-1 Reverse Transcriptase with Inhibitors of the HEPT Series Reveal Conformational Changes Relevant to the Design of Potent Non-Nucleoside Inhibitors

Published:1996-01-01 Issue:8 Volume:39 Page:1589-1600
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hopkins Andrew L.¹,Ren Jingshan¹,Esnouf Robert M.¹,Willcox Benjamin E.¹,Jones E. Yvonne¹,Ross Carl¹,Miyasaka Tadashi¹,Walker Richard T.¹,Tanaka Hiromichi¹,Stammers David K.¹,Stuart David I.¹

Affiliation:

1. The Laboratory of Molecular Biophysics, Rex Richards Building, South Parks Road, Oxford, OX1 3QU, U.K., The Oxford Centre for Molecular Sciences, New Chemistry Building, South Parks Road, Oxford, OX1 3QT, U.K., Structural Biology Group, The Glaxo-Wellcome Research Laboratories, Langley Court, Beckenham, Kent, BR3 3BS, U.K., School of Pharmaceutical Sciences, Showa University, Hatanodai 1-5-8, Shinagawa-ku, Tokyo 142, Japan, and School of Chemistry, The University of Birmingham, Edgbaston, Birmingham, B15...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm960056x

Reference65 articles.

1. 3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.

2. Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides.

3. In Vivo Activity Against HIV and Favorable Toxicity Profile of 2′,3′-Dideoxyinosine

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