“Lead Hopping”. Validation of Topomer Similarity as a Superior Predictor of Similar Biological Activities-Reference-Cited by-同舟云学术

“Lead Hopping”. Validation of Topomer Similarity as a Superior Predictor of Similar Biological Activities

Published:2004-12-01 Issue:27 Volume:47 Page:6777-6791
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cramer Richard D.¹,Jilek Robert J.¹,Guessregen Stefan¹,Clark Stephanie J.¹,Wendt Bernd¹,Clark Robert D.¹

Affiliation:

1. Tripos Discovery Research, Bude-Stratton Business Park, Bude, Cornwall, EX23 8LY, U.K., and Tripos Inc., 1699 South Hanley Road, St. Louis, Missouri 63144

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm049501b

Reference43 articles.

1. Neighborhood Behavior: A Useful Concept for Validation of “Molecular Diversity” Descriptors

2. Selecting Optimally Diverse Compounds from Structure Databases: A Validation Study of Two-Dimensional and Three-Dimensional Molecular Descriptors

3. Substructural analysis. Novel approach to the problem of drug design

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