A Direct and Efficient Total Synthesis of the Tubulin-Binding Agents Ceratamine A and B; Use of IBX for a Remarkable Heterocycle Dehydrogenation
Author:
Affiliation:
1. Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ol900709n
Reference27 articles.
1. Ceratamines A and B, Antimitotic Heterocyclic Alkaloids Isolated from the Marine Sponge Pseudoceratina sp. Collected in Papua New Guinea
2. Natural, semisynthetic and synthetic microtubule inhibitors for cancer therapy
3. Microtubules as a target for anticancer drugs
4. Ceratamines, Structurally Simple Microtubule-Stabilizing Antimitotic Agents with Unusual Cellular Effects
5. Structure of tubulin at 6.5 Å and location of the taxol-binding site
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