Synthesis of GABAA Receptor Agonists and Evaluation of their α-Subunit Selectivity and Orientation in the GABA Binding Site-Reference-Cited by-同舟云学术

Synthesis of GABAA Receptor Agonists and Evaluation of their α-Subunit Selectivity and Orientation in the GABA Binding Site

Published:2008-07-24 Issue:15 Volume:51 Page:4430-4448
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Jansen Michaela¹,Rabe Holger¹,Strehle Axelle¹,Dieler Sandra¹,Debus Fabian¹,Dannhardt Gerd¹,Akabas Myles H.¹,Lüddens Hartmut¹

Affiliation:

1. Department of Medicinal Chemistry and Department of Psychiatry, Johannes Gutenberg-University, Mainz, Germany, and Departments of Physiology & Biophysics, Neuroscience and Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm701562x

Reference72 articles.

1. theta , a novel gamma -aminobutyric acid type A receptor subunit

2. GABAAReceptor ε and θ Subunits Display Unusual Structural Variation between Species and Are Enriched in the Rat Locus Ceruleus

3. Four Amino Acids in the α Subunits Determine the γ-Aminobutyric Acid Sensitivities of GABAA Receptor Subtypes

4. Subunit Composition, Distribution and Function of GABA-A Receptor Subtypes

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