Optimization of Grignard Addition to Esters: Kinetic and Mechanistic Study of Model Phthalide Using Flow Chemistry-Reference-Cited by-同舟云学术

Optimization of Grignard Addition to Esters: Kinetic and Mechanistic Study of Model Phthalide Using Flow Chemistry

Published:2018-03-21 Issue:14 Volume:57 Page:4859-4866
ISSN:0888-5885
Container-title:Industrial & Engineering Chemistry Research
language:en
Short-container-title:Ind. Eng. Chem. Res.

Author:

Pedersen Michael J.¹²³^ORCID,Born Stephen²,Neuenschwander Ulrich²,Skovby Tommy¹,Mealy Michael J.¹,Kiil Søren³,Dam-Johansen Kim³,Jensen Klavs F.²^ORCID

Affiliation:

1. H. Lundbeck A/S, Oddenvej 182, 4500 Nykøbing Sjælland, Denmark

2. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

3. Department of Chemical and Biochemical Engineering, Technical University of Denmark, Building 229, 2800 Kongens Lyngby, Denmark

Funder

Novartis

Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung

Massachusetts Institute of Technology

Lundbeck A/S

Publisher

American Chemical Society (ACS)

Subject

Industrial and Manufacturing Engineering,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.iecr.8b00564

Reference75 articles.

1. Handbook of Grignard Reagents

2. Organometallic reaction mechanisms. VIII. Detailed description of the mechanism of methylmagnesium bromide addition to 2-methylbenzophenone

3. Über die Konstitution der Grignardschen Magnesiumverbindungen

4. The Mechanism of Addition of Grignard Reagents to Ketones

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