Viscosity Reduction of a Concentrated Monoclonal Antibody with Arginine·HCl and Arginine·Glutamate-Reference-Cited by-同舟云学术

Viscosity Reduction of a Concentrated Monoclonal Antibody with Arginine·HCl and Arginine·Glutamate

Published:2016-10-21 Issue:43 Volume:55 Page:11225-11234
ISSN:0888-5885
Container-title:Industrial & Engineering Chemistry Research
language:en
Short-container-title:Ind. Eng. Chem. Res.

Author:

Borwankar Ameya U.¹,Dear Barton J.¹,Twu April¹,Hung Jessica J.¹,Dinin Aileen K.¹,Wilson Brian K.¹,Yue Jingyan¹,Maynard Jennifer A.¹,Truskett Thomas M.¹,Johnston Keith P.¹

Affiliation:

1. McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States

Funder

Welch Foundation

AbbVie

National Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Industrial and Manufacturing Engineering,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.iecr.6b02042

Reference70 articles.

1. Complexation Hydrogels as Oral Delivery Vehicles of Therapeutic Antibodies: An in Vitro and ex Vivo Evaluation of Antibody Stability and Bioactivity

2. Challenges in the development of high protein concentration formulations

3. Non-Aqueous Suspensions of Antibodies are Much Less Viscous Than Equally Concentrated Aqueous Solutions

4. Highly Viscous Antibody Solutions Are a Consequence of Network Formation Caused by Domain–Domain Electrostatic Complementarities: Insights from Coarse-Grained Simulations

5. Low Viscosity Highly Concentrated Injectable Nonaqueous Suspensions of Lysozyme Microparticles

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