Relating Collective Diffusion, Protein–Protein Interactions, and Viscosity of Highly Concentrated Monoclonal Antibodies through Dynamic Light Scattering-Reference-Cited by-同舟云学术

Relating Collective Diffusion, Protein–Protein Interactions, and Viscosity of Highly Concentrated Monoclonal Antibodies through Dynamic Light Scattering

Published:2019-08-30 Issue:50 Volume:58 Page:22456-22471
ISSN:0888-5885
Container-title:Industrial & Engineering Chemistry Research
language:en
Short-container-title:Ind. Eng. Chem. Res.

Author:

Dear Barton J.¹,Chowdhury Amjad¹^ORCID,Hung Jessica J.¹,Karouta Carl A.¹,Ramachandran Kishan¹,Nieto Maria P.¹,Wilks Logan R.¹,Sharma Ayush¹,Shay Tony Y.¹,Cheung Jason K.²,Truskett Thomas M.¹³^ORCID,Johnston Keith P.¹^ORCID

Affiliation:

1. McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States

2. Biophysical and Biochemical Characterization, Sterile Formulation Sciences, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States

3. Department of Physics, The University of Texas at Austin, Austin, Texas 78712, United States

Funder

Welch Foundation

Merck Sharp and Dohme

Pfizer

Publisher

American Chemical Society (ACS)

Subject

Industrial and Manufacturing Engineering,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.iecr.9b03432

Reference105 articles.

1. Reichert, J. M. Therapeutic monoclonal antibodies approved or in review in the European Union or United States. http://www.antibodysociety.org/news/approved_mabs.php (accessed 1/15/2015).

2. Potent antibody therapeutics by design

3. Challenges in the development of high protein concentration formulations

4. Protein aggregation and its impact on product quality

5. Advanced protein formulations

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