Effect of the F610A Mutation on Substrate Extrusion in the AcrB Transporter: Explanation and Rationale by Molecular Dynamics Simulations-Reference-Cited by-同舟云学术

Effect of the F610A Mutation on Substrate Extrusion in the AcrB Transporter: Explanation and Rationale by Molecular Dynamics Simulations

Published:2011-06-27 Issue:28 Volume:133 Page:10704-10707
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Vargiu Attilio V.¹,Collu Francesca¹²,Schulz Robert³,Pos Klaas M.⁴,Zacharias Martin⁵,Kleinekathöfer Ulrich³,Ruggerone Paolo²

Affiliation:

1. CNR-IOM, Unità SLACS, S.P. Monserrato-Sestu Km 0.700, I-09042 Monserrato (CA), Italy

2. Department of Physics, University of Cagliari, S.P. Monserrato-Sestu Km 0.700, I-09042 Monserrato (CA), Italy

3. School of Engineering and Science, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany

4. Cluster of Excellence Frankfurt - Macromolecular Complexes and Institute of Biochemistry, Goethe University Frankfurt, Max-von-Laue-Str.9, D-60438 Frankfurt am Main, Germany

5. Physik-Department, Technische Universität München, James-Franck-Str. 1, D-85748 Garching, Germany

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja202666x

Reference46 articles.

1. Antibiotics for Emerging Pathogens

2. Structure, function and inhibition of RND efflux pumps in Gram-negative bacteria: an update

3. Multiple molecular mechanisms for multidrug resistance transporters

4. Molecular Mechanisms of Antibacterial Multidrug Resistance

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