Discovery of γ-Secretase Modulators with a Novel Activity Profile by Text-Based Virtual Screening-Reference-Cited by-同舟云学术

Discovery of γ-Secretase Modulators with a Novel Activity Profile by Text-Based Virtual Screening

Published:2012-07-02 Issue:9 Volume:7 Page:1488-1495
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Zettl Heiko¹,Ness Julia²,Hähnke Volker¹,Beher Dirk³,Jumpertz Thorsten²,Saric Arman³,Baumann Karlheinz⁴,Pietrzik Claus U.⁵,Bulic Bruno⁶,Schneider Gisbert¹,Weggen Sascha²

Affiliation:

1. Institute of Pharmaceutical Sciences, ETH Zurich, CH-8093 Zurich, Switzerland

2. Department of Neuropathology, Heinrich-Heine-University, D-40225 Duesseldorf, Germany

3. Global Research & Early Development, Merck Serono S. A., CH-1202 Geneva, Switzerland

4. F. Hoffmann-La Roche AG, pRED, Pharma Research & Early Development, DTA CNS, CH-4070 Basel, Switzerland

5. Institute of Pathobiochemistry, University Medical Center of the Johannes Gutenberg-University, D-55128 Mainz, Germany

6. Research Group Chemical Biology of Neurodegenerative Diseases, Center of Advanced European Studies and Research, D-53175 Bonn, Germany

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/cb3001952

Reference23 articles.

1. PhAST: Pharmacophore alignment search tool

2. Pharmacophore alignment search tool: Influence of canonical atom labeling on similarity searching

3. Exploring the chemical space of γ-secretase modulators

4. γ-secretases: from cell biology to therapeutic strategies

5. Secretase inhibitors and modulators for Alzheimer’s disease treatment

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